Topological estimation of proton-ligand formation constants of potential antitumour agents: Salicylhydroxamic acids

Journal of Chemical Sciences

Shobha Joshi²  Vijay K Agrawal³  Keshav C Mathur³  Sneha Karmarkar¹  Manorama Mandloi²  P V Khadikar1¹ 

[1] Research Division, Laxmi Pest & Fumigation Pvt. Ltd., 3 Khatipura, Indore 452 007, India$$;Department of Chemistry, Model Holkar Science College, Indore, 452 001 India$$;Department of Chemistry, APS University, Rewa 486 003, India$$

关键词: Salicylhydroxamic acids;    antitumour agents;    topological indices;    normalized Wiener index;    mean square Wiener index.;   

DOI  :  

来源: Indian Academy of Sciences

【 摘 要 】

Proton-ligand formation constants of salicylhydroxamic acids (SHA) and their nuclear substituted derivatives have been estimated topologically using the normalized Wiener index, referred to as mean square Wiener index (Wms). Regression analysis of the data indicates that Wms can be used successfully for estimating and monitoring proton-ligand formation constants.

【 授权许可】

Unknown