NLRP3 polymorphism is associated with protection against human T-lymphotropic virus 1 infection

Memórias do Instituto Oswaldo Cruz

Anselmo Jiro Kamada¹  Alessandra Pontillo¹  Rafael Lima Guimarães¹  Paula Loureiro¹  Sergio Crovella¹  Lucas André Cavalcanti Brandão¹ 

关键词: NLRP3;    NLRP1;    single nucleotide polymorphisms;    innate immunity;    HTLV-1;   

DOI  :  10.1590/0074-0276140154

来源: SciELO

【 摘 要 】

Inter-individual heterogeneity in the response to human T-lymphotropic virus 1 (HTLV-1) infection has been partially attributed to host genetic background. The antiviral activity of the inflammasome cytoplasmic complex recognises viral molecular patterns and regulates immune responses via the activation of interleukin (IL)-1 family (IL-1, IL-18 and IL-33) members. The association between polymorphisms in the inflammasome receptors NLRP1 and NLRP3 and HTLV-1 infection was evaluated in a northeastern Brazilian population (84 HTLV-1 carriers and 155 healthy controls). NLRP3 rs10754558 G/G was associated with protection against HTLV-1 infection (p = 0.012; odds ratio = 0.37). rs10754558 affects NLRP3 mRNA stability; therefore, our results suggest that higher NLRP3 expression may augment first-line defences, leading to the effective protection against HTLV-1 infection.

【 授权许可】

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