Vitiligo: Mechanistic insights lead to novel treatments

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:140

Article

Frisoli, Michael L.¹  Harris, John E.¹ 

[1] Univ Massachusetts, Med Sch, Dept Dermatol, 364 Plantat St,LRB 225, Amherst, MA 01605 USA

关键词: Vitiligo;    treatment;    T cell;    IFN-gamma;    CXCL9;    CXCL10;    CXCR3;    resident memory;    regulation;    stress;    innate immunity;    inflammasome;    NLRP1;    NLRP3;    melanocyte;    regeneration;    clinical trials;    repigmentation;    hair;   

DOI  :  10.1016/j.jaci.2017.07.011

来源: Elsevier

【 摘 要 】

Vitiligo is an autoimmune disease of the skin characterized by patchy depigmentation. Current treatments are moderately effective at reversing disease by suppressing autoimmune inflammation in the skin and promoting melanocyte regeneration. Recent basic and translational research studies have significantly improved our understanding of disease pathogenesis, which is now leading to emerging treatment strategies based on targeted therapy. Here we discuss important clinical characteristics of vitiligo, current therapies and their limitations, advances in understanding disease pathogenesis, emerging targeted treatments, and strategies to optimize clinical trials to efficiently and effectively test these new treatments.

【 授权许可】

Free