Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?

Memórias do Instituto Oswaldo Cruz

Fernando Fonseca Val¹  Vanderson Souza Sampaio¹  Maria Belén Cassera¹  Raquel Tapajós Andrade¹  Pedro Luiz Tauil¹  Wuelton Marcelo Monteiro¹  Marcus Vinícius Guimarães Lacerda¹ 

关键词: malaria;    Plasmodium;    elimination;    control;    antimalarials;    salt;   

DOI  :  10.1590/0074-0276140240

来源: SciELO

【 摘 要 】

In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned. More than 50 years later, asexual stage resistance can be avoided by screening for antimalarial drugs that have a selective action against gametocytes, thus old prophylactic measures can be revisited. The efficacy of the old methods should be tested as complementary tools for the elimination of malaria.

【 授权许可】

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