Phaeohyphomycosis: a clinical-epidemiological and diagnostic study of eighteen cases in Rio Grande do Sul, Brazil

Memórias do Instituto Oswaldo Cruz

Cecília Bittencourt Severo²  Flávio De Mattos Oliveira²  Emily Ferreira Salles Pilar¹  Luiz Carlos Severo² 

[1] ,Irmandade Santa Casa de Misericórdia de Porto Alegre Laboratório de Micologia Porto Alegre RS ,Brasil

关键词: phaeohyphomycosis;    solid organ transplants;    Exophiala jeanselmei;    Alternaria sp.;    Curvularia sp.;    Colletotrichum gloeosporioides;   

DOI  :  10.1590/S0074-02762012000700003

来源: SciELO

【 摘 要 】

The goal of this study was to review 18 cases of phaeohyphomycosis in Rio Grande do Sul. The records of all of the patients with a diagnosis of phaeohyphomycosis between 1995-2010 were reviewed. Twelve of the 18 patients (66.6%) were male. The average age of the patients was 50 years old (range: 16-74 years). Eleven patients (61%) presented with subcutaneous lesions. Seven patients (38.8%) had received a solid organ transplant. In all of the cases, the presence of melanin in the fungal cells was determined by Fontana-Masson staining of tissue sections and documented. Among the 18 patients, a total of 11 different fungal species were isolated. The causative organisms included Exophiala jeanselmei, Alternaria, Curvularia, Cladophialophora and Colletotrichum gloeosporioides. To our knowledge, this review reports the first case of subcutaneous phaeohyphomycosis caused by C. gloeosporioides in a lung transplant patient. The number of reported cases of phaeohyphomycosis has increased in the last decade. In a number of cases, this increased incidence may be primarily attributed to iatrogenic immunodeficiency.

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