Alternariol 9-methyl ether from the endophytic fungus Alternaria sp. Samif01 and its bioactivities

Revista de microbiologia

Lou, Jingfeng¹  Yu, Ruiting² 

[1] China Agricultural University, Beijing, China;Chinese Academy of Agricultural Sciences, Beijing, China

关键词: Salvia miltiorrhiza Bunge;    Endophytic fungus;    Alternaria sp.;    Alternariol 9-methyl ether;    Bioactivity.;   

DOI  :  10.1016/j.bjm.2015.11.004

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Microbiologia / Brazilian Society for Microbiology

【 摘 要 】

One bioactive compound, identified as alternariol 9-methyl ether, was isolated from the crude extract of the endophytic fungus Alternaria sp. Samif01 residing in the roots of Salvia miltiorrhiza Bunge. Alternariol 9-methyl ether was active against bacteria with minimum inhibitory concentration values ranging from 25 to 75 µg/mL and median inhibitory concentration (IC50) values ranging from 16.00 to 38.27 µg/mL. The IC50 value of alternariol 9-methyl ether against spore germination of Magnaporthe oryzae was 87.18 µg/mL. Alternariol 9-methyl ether also showed antinematodal activity against Bursaphelenchus xylophilus and Caenorhabditis elegans with IC50 values of 98.17 µg/mL and 74.62 µg/mL, respectively. This work is the first report on alternariol 9-methyl ether and its biological activities from the endophytic fungus Alternaria sp. Samif01 derived from S. miltiorrhiza Bunge. The results indicate the potential of Alternaria sp. Samif01 as a source of alternariol 9-methyl ether and also support that alternariol 9-methyl ether is a natural compound with high potential bioactivity against microorganisms.

【 授权许可】

CC BY-NC