The in vivo antimalarial activity of methylene blue combined with pyrimethamine, chloroquine and quinine

Memórias do Instituto Oswaldo Cruz

Giovanny Garavito²  Stéphane Bertani¹  Miguel Quiliano¹  Alexis Valentin¹  Ignacio Aldana¹  Eric Deharo¹ 

[1] ,Universidad Nacional de Colombia Facultad de Ciencias Departamento de FarmaciaBogotá,Colombia

关键词: antimalarials;    methylene blue;    drug combination;   

DOI  :  10.1590/S0074-02762012000600019

来源: SciELO

【 摘 要 】

The effectiveness of methylene blue (MB) combined with pyrimethamine (PYR), chloroquine (CQ) or quinine (Q) was examined in a classical four-day suppressive test against a causative agent of rodent malaria, Plasmodium berghei. A marked potentiation was observed when MB was administered at a non-curative dose of 15 mg/kg/day in combination with PYR (0.19 mg/kg/day) or Q (25 mg/kg/day). No synergy was found between MB (15 mg/Kg) and CQ (0.75 mg/Kg). Our results suggest that the combination of MB with PYR or Q may improve the efficacy of these currently used antimalarial drugs.

【 授权许可】

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