High prevalence of drug-resistant tuberculosis and other mycobacteria among HIV-infected patients in Brazil: a systematic review

Memórias do Instituto Oswaldo Cruz

Ricardo H Bammann²  Liliana A Zamarioli¹  Valdir S Pinto²  Carla Mp Vázquez²  Marcelo N Litvoc¹  Giselle B Klautau²  Fernando A Fiúza De Melo¹  Nilton J Cavalcante²  Lucilaine Ferrazoli¹ 

[1] ,Instituto de Infectologia Emílio RibasSão Paulo SP ,Brasil

关键词: acquired immunodeficiency syndrome;    tuberculosis;    drug;    resistant;    mycobacterial;    atypical;    Brazil;   

DOI  :  10.1590/S0074-02762010000600019

来源: SciELO

【 摘 要 】

There is a little-noticed trend involving human immunodeficiency virus (HIV)-infected patients suspected of having tuberculosis: the triple-treatment regimen recommended in Brazil for years has been potentially ineffective in over 30% of the cases. This proportion may be attributable to drug resistance (to at least 1 drug) and/or to infection with non-tuberculous mycobacteria. This evidence was not disclosed in official statistics, but arose from a systematic review of a few regional studies in which the diagnosis was reliably confirmed by mycobacterial culture. This paper clarifies that there has long been ample evidence for the potential benefits of a four-drug regimen for co-infected patients in Brazil and it reinforces the need for determining the species and drug susceptibility in all positive cultures from HIV-positive patients.

【 授权许可】

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