Detection of IgG1 and IgG4 subtypes reactive against potato apyrase in schistosomiasis patients

Memórias do Instituto Oswaldo Cruz

Priscila De Faria-pinto²  Rita Gabriela Pedrosa Ribeiro Mendes²  Cristiane De Carvalho-campos²  Ana Carolina Ribeiro Gomes Maia²  Áureo Almeida Oliveira¹  Paulo Marcos Zech Coelho¹  Eveline Gomes Vasconcelos² 

[1] ,Universidade Federal de Juiz de Fora Laboratório de Estrutura e Função de Proteínas Instituto de Ciências BiológicasJuiz de Fora MG ,Brasil

关键词: Schistosoma mansoni;    ATP diphosphohydrolase;    potato apyrase;   

DOI  :  10.1590/S0074-02762010000400004

来源: SciELO

【 摘 要 】

In this paper, we showed for the first time that the conserved domains within Schistosoma mansoni ATP diphosphohydrolase isoforms, shared with potato apyrase, possess epitopes for the IgG1 and IgG4 subtypes, as 24 (80%) of the 30 schistosomiasis patients were seropositive for this vegetable protein. The analyses for each patient cured (n = 14) after treatment (AT) with praziquantel revealed variable IgG1 and IgG4 reactivity against potato apyrase. Different antigenic epitopes shared between the vegetable and parasite proteins could be involved in susceptibility or resistance to S. mansoni AT with praziquantel and these possibilities should be explored.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License