Memórias do Instituto Oswaldo Cruz | |
Molluscicidal activity of Hammada scoparia (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula | |
R Mezghani-jarraya1  H Hammami2  A Ayadi2  M Damak1  | |
[1] ,Faculty of Science Laboratory of Natural Substances Chemistry ,Tunisia | |
关键词: molluscicidal activity; Galba truncatula; Fasciola hepatica; Hammada scoparia; major alkaloids; N-methylisosalsoline; | |
DOI : 10.1590/S0074-02762009000700017 | |
来源: SciELO | |
【 摘 要 】
The molluscicidal activity of Hammada scoparia leaf extracts and the principal alkaloids isolated from them (carnegine and N-methylisosalsoline) were tested against the mollusc gastropod, Galba truncatula, the intermediate host of Fasciola hepatica in Tunisia. The results indicated that the molluscicidal activity was correlated with the presence of alkaloids. A significant molluscicidal value, according to the World Health Organization, was found with the methanol extract (LC50 = 28.93 ppm). Further fractionation of the methanolic extract led to the isolation of two principal alkaloids: carnegine and N-methylisosalsoline. These alkaloids are isoquinolines that have not previously been characterised for their molluscicidal activity. The N-methylisosalsoline possesses the highest molluscicidal activity (LC50 = 0.47 μM against G. truncatula).
【 授权许可】
CC BY
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