Molluscicidal activity of Hammada scoparia (Pomel) Iljin leaf extracts and the principal alkaloids isolated from them against Galba truncatula

Memórias do Instituto Oswaldo Cruz

R Mezghani-jarraya¹  H Hammami²  A Ayadi²  M Damak¹ 

[1] ,Faculty of Science Laboratory of Natural Substances Chemistry ,Tunisia

关键词: molluscicidal activity;    Galba truncatula;    Fasciola hepatica;    Hammada scoparia;    major alkaloids;    N-methylisosalsoline;   

DOI  :  10.1590/S0074-02762009000700017

来源: SciELO

【 摘 要 】

The molluscicidal activity of Hammada scoparia leaf extracts and the principal alkaloids isolated from them (carnegine and N-methylisosalsoline) were tested against the mollusc gastropod, Galba truncatula, the intermediate host of Fasciola hepatica in Tunisia. The results indicated that the molluscicidal activity was correlated with the presence of alkaloids. A significant molluscicidal value, according to the World Health Organization, was found with the methanol extract (LC50 = 28.93 ppm). Further fractionation of the methanolic extract led to the isolation of two principal alkaloids: carnegine and N-methylisosalsoline. These alkaloids are isoquinolines that have not previously been characterised for their molluscicidal activity. The N-methylisosalsoline possesses the highest molluscicidal activity (LC50 = 0.47 μM against G. truncatula).

【 授权许可】

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