Molluscicidal activity of various solvent extracts from Solanum nigrum var. villosum L. aerial parts against Galba truncatula

Parasite

and A. Ayadi²  M. Damak¹  R. Mezghani-Jarraya¹  H. Hammami² 

[1] Laboratory of Chemistry of Natural Products, Faculty of Science, University of Sfax,Tunisia;Fungal and Parasitic Molecular Biology Laboratory, Faculty of Medicine, University of Sfax,3029,Sfax,Tunisia

关键词: saponosides;    alkaloids;    Solanum nigrum var. villosum L.;    Fasciola hepatica;    Galba truncatula;    molluscicidal activity;   

Others  :  808886
DOI  :  doi:10.1051/parasite/2011181063

 received in 2009-11-04, accepted in 2010-06-09,  发布年份 2011

【 摘 要 】

Molluscicidal activity of Solanum nigrum var. villosum (morelle velue) extracts and their fractions were tested against the mollusca gastropoda Galba truncatula intermediate host of Fasciola hepatica. The results indicated that the hydro-methanol (MeOH-H2O) immature fruit extract possess the highest molluscicidal activity (LC50 = 3.96 mg/L) against Galba truncatula compared with other tested compounds. After acido-basic treatment, the methanolic extract fraction isolated from the immature fruits and the richest in alkaloids was the most toxic (LC50 = 1.65 mg/L). The fractions richest in saponosides obtained from the hydromethanolic and methanolic extracts of immature fruits showed interesting molluscicidal activities (LC50 = 6.15 mg/L and LC50 = 7.91 mg/L, respectively). The observed molluscicide activity could be attributed to the presence of alkaloids or saponosides. So, the immature fruits of Solanum nigrum var. villosum could be substrates of choice for molluscicide activity. In addition, total alkaloids and saponosides present in this plant deserve further investigations in order to identify the active principles and demonstrate their activities on mollusks in their natural habitat. According to the World Health Organization’s guidelines on screening for plant molluscicides, use of these fractions may add to the arsenal of methods to control snail transmitting fasciolosis in tropical and Third World countries where fasciolosis is a common disease.

【 授权许可】

   
© PRINCEPS Editions, Paris, 2011

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