Seroprevalence of HBV, HCV and HIV co-infection in selected individuals from state of São Paulo, Brazil

Memórias do Instituto Oswaldo Cruz

Alexandre Martins Portelinha Filho²  Charles Ulloffo Do Nascimento²  Talita Nicastro Tannouri²  Charlene Troiani¹  Eloah Lopes Ascêncio¹  Renata Bonfim¹  Lourdes Aparecida Zampieri D'andrea¹  Luiz Euribel Prestes-carneiro¹ 

[1] ,Hospital Universitário Departamento de Doenças Infecciosas

关键词: hepatitis B virus;    hepatitis C virus;    human immunodeficiency virus co-infection;    HCV genotypes;    seroprevalence;    São Paulo;   

DOI  :  10.1590/S0074-02762009000700003

来源: SciELO

【 摘 要 】

Few studies are available on hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection in populations living in small and medium-sized Brazilian cities. We evaluated the seroprevalence of these viruses in selected individuals from a clinic of infectology, who were referred to the University Regional Hospital of the West Region of state of São Paulo, Brazil. Among a total of 7,021 individuals seen in the clinic following receipt of preliminary ELISA results or having the suggested clinical signs of viral hepatitis or HIV, 1,228 were systematically screened. Isolated or associated HBsAg, HCV and HIV antibodies were found in 44.9% of the subjects. Anti-HIV antibodies were found in 24.7% of the patients, 20.3% of whom had an HIV monoinfection and 4.4% of whom were co-infected with hepatitis viruses (HCV: 4%; HBV: 0.4%). Anti-HCV antibodies were found in 14% of the patients and 5.9% had anti-HBsAg antibodies. HCV infection affected males more than females (p < 0.05) and individuals > 50-years old had an increased prevalence of anti-HCV compared to HIV (p = 0.0001) or HBV (p = 0.0063). HCV-RNA was detected in 73.5% of the samples with a predominance of genotype 1 (72.5%). A significant percentage (44.9%) of the selected individuals was positive for antibodies against HBV, HCV and/or HIV; these patients would otherwise have remained undiagnosed.

【 授权许可】

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