Veterinary vaccines against Toxoplasma gondii

Memórias do Instituto Oswaldo Cruz

Elisabeth A Innes¹  Paul M Bartley¹  Stephen Maley¹  Frank Katzer¹  David Buxton¹ 

[1] ,Pentlands Science Park Moredun Research Institute Edinburgh

关键词: Toxoplasma gondii;    veterinary;    vaccine;   

DOI  :  10.1590/S0074-02762009000200018

来源: SciELO

【 摘 要 】

Toxoplasma gondii has a very wide intermediate host range and is thought to be able to infect all warm blooded animals. The parasite causes a spectrum of different diseases and clinical symptoms within the intermediate hosts and following infection most animals develop adaptive humoral and cell-mediated immune responses. The development of protective immunity to T. gondii following natural infection in many host species has led researchers to look at vaccination as a strategy to control disease, parasite multiplication and establishment in animal hosts. A range of different veterinary vaccines are required to help control T. gondii infection which include vaccines to prevent congenital toxoplasmosis, reduce or eliminate tissue cysts in meat producing animals and to prevent oocyst shedding in cats. In this paper we will discuss some of the history, challenges and progress in the development of veterinary vaccines against T. gondii.

【 授权许可】

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