Mechanisms of eosinophil cytokine release

Memórias do Instituto Oswaldo Cruz

Christianne Bandeira-melo¹  Peter F Weller² 

[1] ,Fiocruz Instituto Oswaldo Cruz Departamento de Fisiologia e FarmacodinâmicaRio de Janeiro RJ ,Brasil

关键词: eosinophils;    cytokines;    degranulation;   

DOI  :  10.1590/S0074-02762005000900013

来源: SciELO

【 摘 要 】

Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both within specific granules and associated with substantial numbers of morphologically distinct cytoplasmic vesicles. Stimulation for release of specific cytokines, such as IL-4, leads to a regulated signal transduction cascade, which is dependent on the formation of leukotriene C4 within eosinophils where it acts as an intracrine mediator. IL-4 release occurs selectively and is by means of vesicular transport. The capabilities of eosinophils not only to rapidly release pre-formed cytokines but also to differentially regulate which cytokines are released endow eosinophils with distinct abilities in innate and acquired immunity.

【 授权许可】

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