Ticks, ivermectin, and experimental Chagas disease

Memórias do Instituto Oswaldo Cruz

João Carlos Pinto Dias²  Christopher J Schofield¹  Evandro Mm Machado²  Alexandre José Fernandes² 

[1] ,Centro de Pesquisas René Rachou

关键词: Chagas disease;    Trypanosoma cruzi;    Rhipicephalus sanguineus;    ivermectin;    Triatominae;   

DOI  :  10.1590/S0074-02762005000800002

来源: SciELO

【 摘 要 】

Following an infestation of dogticks in kennels housing dogs used for long-term studies of the pathogenesis of Chagas disease, we examined the effect of ivermectin treatment on the dogs, ticks, trypanosome parasites, and also on triatomine vectors of Chagas disease. Ivermectin treatment was highly effective in eliminating the ticks, but showed no apparent effect on the dogs nor on their trypanosome infection. Triatominae fed on the dogs soon after ivermectin treatment showed high mortality, but this effect quickly declined for bugs fed at successive intervals after treatment. In conclusion, although ivermectin treatment may have a transient effect on peridomestic populations of Triatominae, it is not the treatment of choice for this situation. The study also showed that although the dogticks could become infected with Trypanosoma cruzi, this only occurred when feeding on dogs in the acute phase of infection, and there was no evidence of subsequent parasite development in the ticks.

【 授权许可】

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