Evaluation of the toxic effects of doramectin, ivermectin and eprinomectin against Triatoma infestans using a rat model

Biomédica: revista del Instituto Nacional de Salud

卷:37

Martín Dadé¹  Martín Daniele²  Nora Mestorino² 

[1] Laboratorio de Estudios Farmacológicos y Toxicológicos, Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Buenos Aires, ArgentinaCátedra de Farmacología Básica, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina;

[2] Laboratorio de Estudios Farmacológicos y Toxicológicos, Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Buenos Aires, Argentina;

关键词: Triatoma;    Trypanosoma cruzi;    Chagas disease;    insecticide resistance;    vector control;    ivermectin;    Wistar, rats.;   

DOI  :  10.7705/biomedica.v37i3.3316

来源: DOAJ

【 摘 要 】

Introduction: Pyrethroids have been frequently and intensively used for controlling the triatomine vectors of Trypanosoma cruzi. The emergence of resistance to these insecticides has resulted in an urgent need to identify novel, alternative and complementary control strategies.Objective: To evaluate the toxic effects of ivermectin, doramectin and eprinomectin on the bloodfeeding behaviour of Triatoma infestans using a rodent model.Materials and methods: Fifth instar nymphs of T. infestans were fed at different times on Wistar rats pretreated with doramectin, ivermectin, eprinomectin or dimethylsulfoxide (excipient control) topically or orally administered. We determined the effects of each insecticide and of dimethyl sulfoxide on the amount of ingested blood, the volume of faecal discharge, and the mortality rates in triatomines.Results: Only the rate of triatomine mortality was associated with the antiparasitic compounds administered and the route of administration utilized. Doramectin administration was associated with a higher mortality rate (21.5%) than ivermectin, eprinomectin and dimethylsulfoxide (16, 11 and 2.5%, respectively), and topical administration was found to be most effective for inducing mortality (23 vs. 9.3 %).Conclusion: These results demonstrate the toxic effects of the three assessed insecticides on T. infestans. The administration of ecto/endoparasiticides to domiciliary or peridomiciliary animals may serve as an interesting complementary strategy to the use of pyrethroids for the control of T. infestans.

【 授权许可】

Unknown