Evaluation of five screening tests licensed in Argentina for detection of hepatitis C virus antibodies

Memórias do Instituto Oswaldo Cruz

Viviana Ré²  Sandra Gallego²  Elena Treviño¹  Gabriela Barbás²  Claudia Domínguez¹  Osvaldo Elbarcha¹  Héctor Bepre¹  Marta Contigiani² 

[1] ,Instituto de Virología 'Dr. J. M. Vanella' Facultad de Ciencias Medicas

关键词: hepatitis C virus (HCV);    HCV screening test;    sensitivity;   

DOI  :  10.1590/S0074-02762005000300016

来源: SciELO

【 摘 要 】

This study was conducted to compare among the most recent generation of five screening tests licensed in Argentina, in order to evaluate which of the tests has the best sensitivity for detection of antibodies against hepatitis C virus (HCV). The tests analyzed were: Detect-HCV™ (3.0) Biochem ImmunoSystems, Canada; Hepatitis C EIA Wiener Lab., Argentina; Equipar HCV Ab, Italy; Murex HCV 4.0, UK and Serodia-HCV particles agglutination test, Japan. The results obtained showed high discrepancy between the different kits used and show that some of the tests assessed have a low sensitivity for anti-HCV detection in both chronic infections and early seroconversion, and indicate that among the commercially available kits in Argentina, Murex HCV 4.0 (UK) and Serodia-HCV particles agglutination test (Japan) have the best sensitivity for HCV screening. Although the sensitivity of the assays is the first parameter to be considered for blood screening, more studies should be carried out to assess the specificity of such assays.

【 授权许可】

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