Screening of Brazilian basidiomycetes for antimicrobial activity

Memórias do Instituto Oswaldo Cruz

Luiz Henrique Rosa¹  Kátia M Gomes Machado¹  Camila Cristina Jacob²  Marina Capelari¹  Carlos Augusto Rosa¹  Carlos Leomar Zani² 

[1] ,Centro de Pesquisas René Rachou-Fiocruz Laboratório de Química de Produtos Naturais Belo Horizonte MG ,Brasil

关键词: antibiotics;    bacteria;    basidiomycetes;    fungi;    yeasts;   

DOI  :  10.1590/S0074-02762003000700019

来源: SciELO

【 摘 要 】

A total of 103 isolates of basidiomycetes, representing 84 species from different Brazilian ecosystems, were evaluated for their antifungal and antibacterial activity in a panel of pathogenic and non-pathogenic microorganisms. Tissue plugs of the fruiting bodies were cultivated in liquid media and the whole culture extracted with ethyl acetate. Crude extracts from Agaricus cf. nigrecentulus, Agrocybe perfecta, Climacodon pulcherrimus, Gloeoporus thelephoroides, Hexagonia hydnoides, Irpex lacteus, Leucoagaricus cf. cinereus, Marasmius cf. bellus, Marasmius sp., Nothopanus hygrophanus, Oudemansiella canarii, Pycnoporus sanguineus, Phellinus sp., and Tyromyces duracinus presented significant activity against one or more of the target microorganisms. Eight isolates were active only against bacteria while three inhibited exclusively the growth of fungi. Two extracts presented wide antimicrobial spectrum and were active against both fungi and bacteria. Differences in the bioactivity of extracts obtained from isolates from the same species were observed.

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