Experimental Neuroschistosomiasis: Inadequacy of the Murine Model

Memórias do Instituto Oswaldo Cruz

Luciana M Silva¹  Carla Neves De Oliveira¹  Zilton A Andrade¹ 

[1] ,Fiocruz Centro de Pesquisas Gonçalo Moniz Laboratório de Patologia ExperimentalSalvador BA ,Brasil

关键词: neuroschistosomiasis;    Schistosoma mansoni;    murine model;   

DOI  :  10.1590/S0074-02762002000400028

来源: SciELO

【 摘 要 】

Neuroschistosomiasis is rarely observed in human pathology, but it is of considerable importance. To investigate its pathogenesis, consequences and response to treatment, an experimental model would be desirable, but is not yet available, in spite of a few indications of a suitable mouse model in the literature. Severe, recent and late Schistosoma mansoni infections in outbred and inbred strains of mice revealed widespread distribution of parasite eggs in several organs, but only exceptionally did eggs reach the encephalus, thus revealing the inadequacy of the mouse as an experimental model for neuroschistosomiasis.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License