Pseudomonas aeruginosa: study of Antibiotic Resistance and Molecular Typing in Hospital Infection Cases in a Neonatal Intensive Care Unit from Rio de Janeiro City, Brazil

Memórias do Instituto Oswaldo Cruz

Mm Loureiro²  Ba De Moraes²  Vlf Mendonça²  Mrr Quadra¹  Gs Pinheiro¹  Md Asensi² 

[1] ,Fiocruz Instituto Oswaldo Cruz Departamento de BacteriologiaRio de Janeiro RJ ,Brasil

关键词: Pseudomonas aeruginosa;    neonatal intensive care unit;    hospital infection;    sepsis;    Rio de Janeiro;    Brazil;   

DOI  :  10.1590/S0074-02762002000300020

来源: SciELO

【 摘 要 】

This study had the objective of to analyze the demographic and bacteriologic data of 32 hospitalized newborns in an neonatal intensive care unit of a public maternity hospital in Rio de Janeiro city, Brazil, seized by Pseudomonas aeruginosa sepsis during a period ranged from July 1997 to July 1999, and to determine the antimicrobial resistance percentage, serotypes and pulsed field gel electrophoresis (PFGE) patterns of 32 strains isolated during this period. The study group presented mean age of 12.5 days, with higher prevalence of hospital infection in males (59.4%) and vaginal delivery (81.2%), than females (40.6%) and cesarean delivery (18.8%), respectively. In this group, 20 (62.5%) patients received antimicrobials before positive blood cultures presentation. A total of 87.5% of the patients were premature, 62.5% presented very low birth weight and 40.6% had asphyxia. We detected high antimicrobial resistance percentage to b-lactams, chloramphenicol, trimethoprim/sulfamethoxazole and tetracycline among the isolated strains. All isolated strains were classified as multi-drug resistant. Most strains presented serotype O11 while PFGE analysis revealed seven distinct clones with isolation predominance of a single clone (75%) isolated from July 1997 to June 1998.

【 授权许可】

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