Hepatitis A Outbreak in a Public School in Rio de Janeiro, Brazil

Memórias do Instituto Oswaldo Cruz

Livia Melo Villar²  Maria Do Carmo Esteves Da Costa¹  Vanessa Salete De Paula²  Ana Maria Coimbra Gaspar² 

[1] ,Fiocruz Instituto Oswaldo Cruz Departamento de VirologiaRio de Janeiro RJ ,Brasil

关键词: hepatitis A virus;    outbreak;    seroepidemiology;    public school;    Rio de Janeiro;    Brazil;   

DOI  :  10.1590/S0074-02762002000300004

来源: SciELO

【 摘 要 】

From June 1 to July 1 1999, an outbreak involving 25 cases of hepatitis A occurred in a public school in Rio de Janeiro, Brazil. Since these cases were notified to the State Health Department, the National Reference Center for Hepatitis Viruses (CNRHV) was required to investigate the extent of hepatitis A virus (HAV) dissemination. Blood samples from all students were tested for IgM and total anti-HAV antibodies using a commercial enzyme-linked immunoassay (ELISA). At the same time, a questionnaire was completed in order to identify possible risk factors for HAV infection. The environmental investigation showed that there was no fecal contamination of the water supply. The epidemiological investigation demonstrated that almost 50% of this population was susceptible to HAV infection and probably person-to-person transmission was the principal mode of virus dissemination. In this situation, a massive vaccination campaign could control the HAV infection.

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