Identification of Novel Membrane Structures in Plasmodium falciparum Infected Erythrocytes

Memórias do Instituto Oswaldo Cruz

Carlos A Clavijo¹  Carlos A Mora¹  Enrique Winograd² 

[1] ,Universidad Nacional de Colombia

关键词: Plasmodium falciparum;    parasite release;    membrane fusion;    parasitophorous vacuolar membrane;   

DOI  :  10.1590/S0074-02761998000100022

来源: SciELO

【 摘 要 】

Little is known about the molecular mechanisms underlying the release of merozoites from malaria infected erythrocytes. In this study membranous structures present in the culture medium at the time of merozoite release have been characterized. Biochemical and ultrastructural evidence indicate that membranous structures consist of the infected erythrocyte membrane, the parasitophorous vacuolar membrane and a residual body containing electron dense material. These are subcellular compartments expected in a structure that arises as a consequence of merozoite release from the infected cell. Ultrastructural studies show that a novel structure extends from the former parasite compartment to the surface membrane. Since these membrane modifications are detected only after merozoites have been released from the infected erythrocyte, it is proposed that they might play a role in the release of merozoites from the host cell

【 授权许可】

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