A comparison of the inhibitory activity of selective PDE4 inhibitors on eosinophil recruitment in guinea pig skin

Memórias do Instituto Oswaldo Cruz

Mauro M Teixeira²  Jm Miotla²  N Cooper¹  Rw Gristwood¹  Pg Hellewell² 

[1] ,National Heart and Lung Institute Imperial College of Medicine Applied PharmacologyLondon,UK

关键词: eosinophils;    phosphodiesterase inhibitors;    rolipram;    allergic inflammation;   

DOI  :  10.1590/S0074-02761997000800025

来源: SciELO

【 摘 要 】

The elevation of intracellular cyclic AMP by phosphodiesterase (PDE)4 inhibitors in eosinophils is associated with inhibition of the activation and recruitment of these cells. We have previously shown that systemic treatment with the PDE4 inhibitor rolipram effectively inhibt eosinophil migration in guinea pig skin. In the present study we compare the oral potency and efficacy of the PDE4 inhibitors rolipram, RP 73401 and CDP 840 on allergic and PAF-induced eosinophil recruitment. Rolipram and RP 73401 were equally effective and potent when given by the oral route and much more active than the PDE4 inhibitor CDP 840. We suggest that this guinea pig model of allergic and mediator-induced eosinophil recruitment is both a sensitive and simple tool to test the efficacy and potency of PDE4 inhibitors in vivo.

【 授权许可】

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