Immunological system and Schistosoma mansoni: co-evolutionary immunobiology. What is the eosinophil role in parasite-host relationship?

Memórias do Instituto Oswaldo Cruz

Henrique L Lenzi²  Ronaldo G Pacheco¹  Marcelo Pelajo-machado²  Mônica S Panasco²  Waldemiro S Romanha²  Jane A Lenzi² 

[1] ,Instituto Oswaldo Cruz Departamento de Patologia Rio de Janeiro RJ ,Brasil

关键词: eosinophils;    phylogeny;    Schistosoma mansoni;    egg release;    granuloma;    co-evolution;   

DOI  :  10.1590/S0074-02761997000800005

来源: SciELO

【 摘 要 】

Schistosomes, ancestors and recent species, have pervaded many hosts and several phylogenetic levels of immunity, causing an evolutionary pressure to eosinophil lineage expression and response. Schistosoma mansoni adult worms have capitalized on the apparent adversity of living within the mesenteric veins, using the dispersion of eggs and antigens to other tissues besides intestines to set a systemic activation of several haematopoietic lineages, specially eosinophils and monocytes/macrophages. This activation occurs in bone marrow, spleen, liver, lymph nodes, omental and mesenteric milky spots (activation of the old or primordial and recent or new lymphomyeloid tissue), increasing and making easy the migration of eosinophils, monocytes and other cells to the intestinal periovular granulomas. The exudative perigranulomatous stage of the periovular reaction, which present hystolitic characteristics, is then exploited by the parasites, to release the eggs into the intestinal lumen. The authors hypothesize here that eosinophils, which have a long phylogenic story, could participate in the parasite - host co-evolution, specially with S. mansoni, operating together with monocytes/ macrophages, upon parasite transmission.

【 授权许可】

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