Immunogenicity and antigenicity of the N-term repeat amino acid sequence of the Plasmodium falciparum P126 antigen

Memórias do Instituto Oswaldo Cruz

Dalma Maria Banic²  Marc Bossus¹  Patrick Delplace²  André Tartar¹  Héléne Gras-masse¹  Valérie Conseil²  Christine Mazingue¹  Charles Taisne¹  Daniel Camus¹ 

[1] ,B.P. 39 INSERM U-42 Villeneuve d'Aseq,France

关键词: Plasmodium falciparum;    P126;    synthetic peptide;    vaccine-P126 recombinant;    immunogenicity;    immunization;   

DOI  :  10.1590/S0074-02761992000700025

来源: SciELO

【 摘 要 】

The P126 protein, a parasitosphorus vacuole antigen of Plasmodium falciparum has beenshoen to induce protective immunity in Saimiri and Aotus monkeys. In the present work we investigated its immunogenicity. Our results suggest that the N-term of P126 is poorly immunogenic and antibody response against the P126 could be under a MHC restricted control in C57BL/6(H-2b) mice, which could be problematic in ternms of a use of the P126 in a vaccine program. However, we observed that a synthetic peptide, copying the 6 octapeptide repeat corresponding to the N-term of the P126, induces an antibody response to the native molecule in C57BL/6 non-responder mice. Moreover, the vaccine-P126 recombinant induced anmtibodies against the N-term of the molecule in rabbits while the unprocessed P126 did not.

【 授权许可】

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