Trypanosoma cruzi: experimental Chagas' disease in Rhesus monkeys. II. Ultraestructural and cytochemical studies of peroxidase and acid phosphatase activities

Memórias do Instituto Oswaldo Cruz

Maria De Nazareth Leal De Meirelles¹  Maria Da Glória Bonecini-almeida²  Maria Heleosina Ribeiro Pessoa¹  Bernardo Galvão-castro² 

[1] ,WHO Colaborating Center for Research and Training in Parasitic DiseaseDepartamento de ImunologiaRio de Janeiro,Brasil

关键词: ultrastructural cytochemistry;    peroxidase activity;    acid phosphatase;    Chagas' disease;    rhesus monkeys;   

DOI  :  10.1590/S0074-02761990000200005

来源: SciELO

【 摘 要 】

Ultrastructural and cytochemical studies of peroxidase and acid phosphatase were performed in skin, lymph node and heart muscle tissue of thesus monkeys with experimental Chagas's disease. At the site of inoculation ther was a proliferative reaction with the presence of immature macrophages revealed by peroxidase technique. At the lymph node a difuse inflammatory exudate with mononuclear cells, fibroblasts and immature activated macrophages reproduces the human patrtern of acute Chagas' disease inflamatory lesions. The hearth muscle cells present different degrees of degenerative alterations and a striking increase in the number of lysosomal profiles that exhibit acid hydrolase reaction product. A strong inflammatory reaction was present due to lymphocytic infiltrate or due to eosinophil granulocytes associated to ruptured cells. The present study provides some experimental evidences that the monkey model could be used as a reliable model to characterize histopathological alterations of the human disease.

【 授权许可】

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