Bioquímica da esquistossomose mansônica: VII. Alterações lipídicas das membranas lisossômicas durante a faze inicial da agressão hepática

Memórias do Instituto Oswaldo Cruz

Luiz Erlon Araújo Rodrigues¹ 

[1] ,Universidade Federal da Bahia Instituto de Ciências da Saúde Setor de Bioquímica. Departamento de BiofunçãoSalvador,Brasil

关键词: schistosomiasis mansoni;    lysosomal membranes;    lipidic composition of lysosomes;    pre-egging phase;    esquistossomose mansônica;    membranas lisossômicas;    composição lipídica dos lisossomos;    fase pré-postural;   

DOI  :  10.1590/S0074-02761988000100007

来源: SciELO

【 摘 要 】

Aiming at investigating the changes on the lipidic constitution of hepatic lysosomal membranes at the initial phase of schistosomotic damage, mice have been infected with 30 cercarias and employed for essais in the 30th day if infection. The triacyglycerois decreased from 220 ± 48 µg/mg of total proteins in the control mice, to 165 ± 22µg/mg in the infected ones. Similarily, the free cholesterol, also decreased from 539 ± 80 to 396 ± 54 µg/mg; the cholesterol esters from 270 ± 35 to 216 ± 36 µg/mg and the phosphatidylcholines from 44 ± 5,7 to 31 ± 4,9 µg/mg. The phosphatidylserines the phosphatidylethanolamines and the sphingomyelines increased, respectively from 58 ± 9,7 to 60 ± 8,5, from 72 ± 7,8 to 111 ± 15,7 and from 36 ± 4,9 to 63 ± 7,1 µg/mg. The free fatty acids showed no statistical significance on their variations. They varied from 1,7 ± 0,25 µEq/g in the controls to 1,8 ± 0,39 Eq/g in the infected animals. These results indicated that in the initial phase of hepatic schistosomiasis, before the formation of granulomas, important changes on the lipidic constitution of lysosomal membranes can be detected. It seems that they are provoked by the catabolic excreted by immature or adult worms of Schistosoma mansoni present in the portal vein system.

【 授权许可】

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