Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni

Memórias do Instituto Oswaldo Cruz

Ana Lúcia Coutinho Domingues¹  Tibério Batista De Medeiros¹  Edmundo Pessoa De Almeida Lopes¹ 

[1] ,Universidade Federal de Pernambuco Hospital das Clínicas Recife PE ,Brasil

关键词: schistosomiasis mansoni;    ultrasound;    fibrosis markers;    HS schistosomiasis;    liver fibrosis;   

DOI  :  10.1590/S0074-02762011000700004

来源: SciELO

【 摘 要 】

In this paper, the authors review the literature and share their experience of the principal biological markers of fibrosis for the evaluation of periportal fibrosis (PPF) caused by mansoni schistosomiasis. These biological markers are compared to diagnostic ultrasound (US) scans as means of grading PPF. We also review procollagen type I and III, collagen type IV, laminin, hyaluronic acid (HA), immunoglobulin G, platelets, aspartate aminotransferase to platelet ratio index (APRI) and gamma-glutamyl transpeptidase as markers of the disease. Although there are several good markers for evaluating PPF and portal hypertension, such as HA, platelets or APRI, none can yet replace US. These markers may, however, be used to identify patients at greater risk of developing advanced disease in endemic areas and determine who will need further care and US studies.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License