Gram-scale isolation of isobrucein B and neosergeolide from Picrolemma sprucei Hook. f.

Acta Amazonica

Ellen Cristina Costa Da Silva²  Rodrigo César Das Neves Amorim¹  Wanderli Pedro Tadei¹  Adrian Martin Pohlit¹ 

[1] ,Universidade Federal do Amazonas Instituto de Ciências Exatas Curso de Pós-graduação em Química de Produtos NaturaisManaus Amazonas ,Brazil

关键词: Caferana;    Simaroubaceae;    Quassinoid;    Recrystallization;    Caferana;    Simaroubaceae;    Quassinóide;    Recristalização;   

DOI  :  10.1590/S0044-59672009000100026

来源: SciELO

【 摘 要 】

Quassinoids neosergeolide and isobrucein B, obtained from Picrolemma sprucei, have proven in vitro antitumor, antimalarial, anthelminthic, cytotoxic, insecticide and leishmanicidal activities. There is interest in the in vivo pharmacological study of these natural compounds and their semi-synthetic derivatives, however, the quantities obtained in previous extraction processes have been shown to be a limiting factor for continuation of these studies. Herein, we describe a method for obtaining grams of these quassinoids whose purification relies only on recrystallization.

【 授权许可】

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