Detection of bla KPC-2 in Proteus mirabilis in Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Adriane Borges Cabral¹  Maria Amélia Vieira Maciel¹  Josineide Ferreira Barros¹  Marcelo Maranhão Antunes¹  Ana Catarina Souza Lopes¹ 

关键词: Proteus mirabilis;    blaKPC-2;    Plasmid DNA;   

DOI  :  10.1590/0037-8682-0152-2014

来源: SciELO

【 摘 要 】

INTRODUCTION : Infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing isolates pose a major worldwide public health problem today. METHODS : A carbapenem-resistant Proteus mirabilis clinical isolate was investigated for plasmid profiles and the occurrence of β-lactamase genes. RESULTS : The isolate exhibited resistance to ertapenem and imipenem and was susceptible to meropenem, polymyxin, and tigecycline. Five plasmids were identified in this isolate. DNA sequencing analysis revealed the presence of bla KPC-2 and bla TEM-1 genes. An additional PCR using plasmid DNA confirmed that bla KPC-2 was present in one of these plasmids. Conclusions: We report the detection of bla KPC-2 in P. mirabilis in Brazil for the first time. This finding highlights the continuous transfer of bla KPC between bacterial genera, which presents a serious challenge to the prevention of infection by multidrug-resistant bacteria.

【 授权许可】

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