Clinical and laboratory alterations in dogs naturally infected by Leishmania chagasi

Revista da Sociedade Brasileira de Medicina Tropical

José Cláudio Carneiro De Freitas²  Diana Célia Sousa Nunes-pinheiro²  Belarmino Eugênio Lopes Neto²  Glauco Jonas Lemos Santos²  Cyntia Rafaelle Amaral De Abreu²  Roberta Rocha Braga¹  Rafael De Morais Campos¹  Ligene Fernandes De Oliveira¹ 

[1] ,Universidade Estadual do Ceará Faculdade de Veterinária Programa de Pós-Graduação em Ciências VeterináriasFortaleza CE

关键词: Dogs;    Canine visceral leishmanisis;    Biomarkers;    Anemia;    Uremia;    Hyperglobulinemia;    Cães;    Leishmaniose visceral canina;    Biomarcadores;    Anemia;    Uremia;    Hiperglobulinemia;   

DOI  :  10.1590/S0037-86822012000100006

来源: SciELO

【 摘 要 】

INTRODUCTION: Canine visceral leishmaniasis (CVL) is a zoonotic disease with different clinical manifestations. Parasitism often occurs in bone marrow, but changes have been observed in peripheral blood and serum biochemical parameters. The aim of this study was to evaluate the hematological and biochemical parameters in dogs naturally infected by Leishmania chagasi. METHODS: Eighty-five adult dogs of both sexes and various weights and ages from the Zoonosis Control Center of Fortaleza (CCZ) were used, selected by immunofluorescence assay (IFA) and considered positive with IFA titers greater than 1:40 and by visualizing amastigotes of Leishmania chagasi in smears obtained by bone marrow aspiration. The dogs (n = 85) were grouped according to clinical signs: negative (CN = 7), subclinical (CS = 10), and clinical (CC = 68). Blood samples were collected for determination of hematological and biochemical serum values. The experimental protocol was approved by the CEUA/UECE. RESULTS: The most frequent clinical signs were cachexia (77.9%), keratitis (61.8%), and lymphadenopathy (55.9%), and 86.8% of the animals showed more than one clinical sign characteristic of CVL. In CC were observed reductions in red blood cells (63%), hematocrit (72%), and hemoglobin (62%), as well as leukocytosis (33%), neutropenia (28%), thrombocytopenia (50%), uremia (45%), hyperproteinemia (53%, p<0.05), hypergammaglobulinemia (62%, p<0.01), and hypoalbuminemia (58%). CONCLUSIONS: Animals with the clinical form of the disease demonstrate hematological and biochemical changes consistent with anemia, uremia, hyperproteinemia, and hyperglobulinemia, which present themselves as strong clinical markers of visceral leishmaniasis associated with the signs previously reported.

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