In vitro antifungal activity of fatty acid methyl esters of the seeds of Annona cornifolia A.St.-Hil. (Annonaceae) against pathogenic fungus Paracoccidioides brasiliensis

Revista da Sociedade Brasileira de Medicina Tropical

Luciana Alves Rodrigues Dos Santos Lima²  Susana Johann¹  Patrícia Silva Cisalpino¹  Lúcia Pinheiro Santos Pimenta¹  Maria Amélia Diamantino Boaventura¹ 

[1] ,Universidade Federal de São João Del-ReiDivinópolis MG

关键词: Fatty acid methyl esters;    Antifungal activity;    Paracoccidioides brasiliensis;    Ésteres metílicos de ácidos graxos;    Atividade antifúngica;    Paracoccidioides brasiliensis;   

DOI  :  10.1590/S0037-86822011000600024

来源: SciELO

【 摘 要 】

INTRODUCTION: Fatty acids are abundant in vegetable oils. They are known to have antibacterial and antifungal properties. METHODS: Antifungal susceptibility was evaluated by broth microdilution assay following CLSI (formerly the NCCLS) guidelines against 16 fungal strains of clinical interest. RESULTS: In this work, fatty acid methyl esters (FAME) was able to inhibit 12 clinical strains of the pathogenic fungus Paracoccidioides brasiliensis and were also active in the bioautographic assay against Cladosporium sphaerospermum. CONCLUSIONS: FAME was a more potent antifungal than trimethoprim-sulfamethoxazole against P. brasiliensis under the experimental conditions tested.

【 授权许可】

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