Revista da Sociedade Brasileira de Medicina Tropical | |
In vitro antifungal activity of fatty acid methyl esters of the seeds of Annona cornifolia A.St.-Hil. (Annonaceae) against pathogenic fungus Paracoccidioides brasiliensis | |
Universidade Federal de Minas Gerais, Belo Horizonte1  Boaventura, Maria Amélia Diamantino1  Pimenta, Lúcia Pinheiro Santos1  Lima, Luciana Alves Rodrigues dos Santos1  Cisalpino, Patrícia Silva1  Universidade Federal de São João Del-Rei, Divinópolis1  Johann, Susana1  | |
关键词: Fatty acid methyl esters; Antifungal activity; Paracoccidioides brasiliensis; | |
DOI : 10.1590/S0037-86822011000600024 | |
学科分类:农业科学(综合) | |
来源: Sociedade Brasileira de Medicina Tropical | |
【 摘 要 】
INTRODUCTION: Fatty acids are abundant in vegetable oils. They are known to have antibacterial and antifungal properties.METHODS: Antifungal susceptibility was evaluated by broth microdilution assay following CLSI (formerly the NCCLS) guidelines against 16 fungal strains of clinical interest.RESULTS: In this work, fatty acid methyl esters (FAME) was able to inhibit 12 clinical strains of the pathogenic fungus Paracoccidioides brasiliensis and were also active in the bioautographic assay against Cladosporium sphaerospermum.CONCLUSIONS: FAME was a more potent antifungal than trimethoprim-sulfamethoxazole against P. brasiliensis under the experimental conditions tested.
【 授权许可】
Unknown
【 预 览 】
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RO201912010167508ZK.pdf | 577KB | download |