Occurrence and the susceptibility to antimicrobial agents in Pseudomonas aeruginosa and Acinetobacter sp. at a tertiary hospital in southern Brazil

Revista da Sociedade Brasileira de Medicina Tropical

Gabriele Mariani Machado²  Aldalise Lago¹  Sérgio Roberto Riccardi Fuentefria¹  Daiane Bopp Fuentefria¹ 

[1] ,Universidade de Passo Fundo Instituto de Ciências Biológicas Passo Fundo RS

关键词: MβL;    Bacterial resistance;    Pseudomonas aeruginosa;    Acinetobacter;    MβL;    Resistência bacteriana;    Pseudomonas aeruginosa;    Acinetobacter;   

DOI  :  10.1590/S0037-86822011005000015

来源: SciELO

【 摘 要 】

INTRODUCTION: The main mechanism of emerging resistance in Pseudomonas aeruginosa and Acinetobacter sp. isolates is the production of metallo-β-lactamases (MβLs). MβLs are enzymes capable of hydrolyzing cephalosporins, penicillins and carbapenems, but not monobactams (aztreonam), which are often used as antimicrobial therapy to treat nosocomial infections. METHODS: An observational descriptive and retrospective study was designed to assess the frequency of MβLs among strains of P. aeruginosa and Acinetobacter sp. obtained from a tertiary hospital in southern Brazil. RESULTS: MβL production was observed in 77.6% (n = 173/223) for P. aeruginosa isolates and 22.4% (n = 50/223) of Acinetobacter sp. isolates. The Acinetobacter sp. isolates showed 92.8% sensitivity to amikacin and P. aeruginosa isolates showed 58.9% sensitivity to aztreonam. CONCLUSIONS: The MβL indices determined confirm the global concern with this mechanism of resistance.

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