Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count

Revista da Sociedade Brasileira de Medicina Tropical

Roberta Oliveira De Paula E Silva²  Rafaela Cabral Gonçalves Fabiano²  Moisés Salgado Pedrosa¹  José Roberto Lambertucci¹  Luciana Cristina Dos Santos Silva¹ 

[1] ,Federal University of Minas GeraisBelo Horizonte MG

关键词: Progressive multifocal leukoencephalopathy;    AIDS;    HIV;    CD4+ T-lymphocytes;    JC virus;    Leucoencefalopatia multifocal progressiva;    AIDS;    HIV;    Linfócitos T CD4+;    Vírus JC;   

DOI  :  10.1590/S0037-86822011000100028

来源: SciELO

【 摘 要 】

We present the case of a 31-year-old man with acute manifestation of progressive multifocal leukoencephalopathy (PML) as an AIDS-defining disease. The patient presented with a three-day history of neurological disease, brain lesions without mass effect or contrast uptake and a slightly increased protein concentration in cerebrospinal fluid. A serological test for HIV was positive and the CD4+ T-cell count was 427/mm³. Histological examination of the brain tissue revealed abnormalities compatible with PML. The disease progressed despite antiretroviral therapy, and the patient died three months later. PML remains an important cause of morbidity and mortality among HIV-infected patients.

【 授权许可】

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