Progressive multifocal leukoencephalopathy as an AIDS-defining condition in a patient with high CD4+ T-lymphocyte count

Revista da Sociedade Brasileira de Medicina Tropical

Lambertucci, José Roberto¹  Silva, Luciana Cristina dos Santos¹  Pedrosa, Moisés Salgado¹  Silva, Roberta Oliveira de Paula e¹  Fabiano, Rafaela Cabral Gonçalves¹  Federal University of Minas Gerais, Belo Horizonte¹ 

关键词: Progressive multifocal leukoencephalopathy;    AIDS;    HIV;    CD4+ T-lymphocytes;    JC virus.;   

DOI  :  10.1590/S0037-86822011000100028

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

We present the case of a 31-year-old man with acute manifestation of progressive multifocal leukoencephalopathy (PML) as an AIDS-defining disease. The patient presented with a three-day history of neurological disease, brain lesions without mass effect or contrast uptake and a slightly increased protein concentration in cerebrospinal fluid. A serological test for HIV was positive and the CD4+ T-cell count was 427/mm3. Histological examination of the brain tissue revealed abnormalities compatible with PML. The disease progressed despite antiretroviral therapy, and the patient died three months later. PML remains an important cause of morbidity and mortality among HIV-infected patients.

【 授权许可】

Unknown