Concurrent dengue and malaria in the Amazon region

Revista da Sociedade Brasileira de Medicina Tropical

Vinícius Dos Santos Santana²  Lígia Carolina Lavezzo²  Adriano Mondini²  Ana Carolina Bernardes Terzian²  Roberta Vieira De Moraes Bronzoni²  Andrea Regina Baptista Rossit¹  Ricardo Luiz Dantas Machado¹  Paula Rahal¹  Mara Correa Lelles Nogueira¹  Maurício Lacerda Nogueira² 

[1] ,São José do Rio Preto Medical School Laboratory of Virology São José do Rio Preto SP ,Brazil

关键词: Arboviruses;    Coinfection;    Flaviviruses;    Dengue;    Malaria;    Amazon region;    Arbovírus;    Co-infecção;    Flavivírus;    Dengue;    Malária;    Região Amazônica;   

DOI  :  10.1590/S0037-86822010000500007

来源: SciELO

【 摘 要 】

INTRODUCTION: The Amazon region has extensive forested areas and natural ecosystems, providing favorable conditions for the existence of innumerous arboviruses. Over 200 arboviruses have been isolated in Brazil and about 40 are associated with human disease. Four out of 40 are considered to be of public health importance in Brazil: Dengue viruses (1-4), Oropouche, Mayaro and Yellow Fever. Along with these viruses, about 98% of the malaria cases are restricted to the Legal Amazon region. METHODS: This study aimed to investigate the presence of arboviruses in 111 clinical serum samples from patients living in Novo Repartimento (Pará), Plácido de Castro (Acre), Porto Velho (Rondônia) and Oiapoque (Amapá). The viral RNA was extracted and RT-PCR was performed followed by a Multiplex-Nested-PCR, using Flavivirus, Alphavirus and Orthobunyavirus generic and species-specific primers. RESULTS: Dengue virus serotype 2 was detected in two patients living in Novo Repartimento (Pará) that also presented active Plasmodium vivax infection. CONCLUSIONS: Despite scant data, this situation is likely to occur more frequently than detected in the Amazon region. Finally, it is important to remember that both diseases have similar clinical findings, thus the diagnosis could be made concomitantly for dengue and malaria in patients living or returning from areas where both diseases are endemic or during dengue outbreaks.

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