Concurrent dengue and malaria in the Amazon region

Revista da Sociedade Brasileira de Medicina Tropical

Bronzoni, Roberta Vieira de Moraes¹  Mondini, Adriano¹  São Paulo State University, São José do Rio Preto, Brazil¹  Lavezzo, Lígia Carolina¹  Santana, Vinícius dos Santos¹  Rahal, Paula¹  Machado, Ricardo Luiz Dantas¹  São José do Rio Preto Medical School, São José do Rio Preto, Brazil¹  Terzian, Ana Carolina Bernardes¹  Rossit, Andrea Regina Baptista¹  Nogueira, Maurício Lacerda¹  Nogueira, Mara Correa Lelles¹ 

关键词: Arboviruses;    Coinfection;    Flaviviruses;    Dengue;    Malaria;    Amazon region;   

DOI  :  10.1590/S0037-86822010000500007

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: The Amazon region has extensive forested areas and natural ecosystems, providing favorable conditions for the existence of innumerous arboviruses. Over 200 arboviruses have been isolated in Brazil and about 40 are associated with human disease. Four out of 40 are considered to be of public health importance in Brazil: Dengue viruses (1-4), Oropouche, Mayaro and Yellow Fever. Along with these viruses, about 98% of the malaria cases are restricted to the Legal Amazon region.METHODS: This study aimed to investigate the presence of arboviruses in 111 clinical serum samples from patients living in Novo Repartimento (Pará), Plácido de Castro (Acre), Porto Velho (Rondônia) and Oiapoque (Amapá). The viral RNA was extracted and RT-PCR was performed followed by a Multiplex-Nested-PCR, using Flavivirus, Alphavirus and Orthobunyavirus generic and species-specific primers.RESULTS: Dengue virus serotype 2 was detected in two patients living in Novo Repartimento (Pará) that also presented active Plasmodium vivax infection.CONCLUSIONS: Despite scant data, this situation is likely to occur more frequently than detected in the Amazon region. Finally, it is important to remember that both diseases have similar clinical findings, thus the diagnosis could be made concomitantly for dengue and malaria in patients living or returning from areas where both diseases are endemic or during dengue outbreaks.

【 授权许可】

Unknown