Hepatitis C virus and human T-lymphotropic virus coinfection: epidemiological, clinical, laboratory and histopathological features

Revista da Sociedade Brasileira de Medicina Tropical

Flávio Augusto Pádua Milagres²  Maria Irma Seixas Duarte¹  Ana Teresa Viso²  Aluisio Cotrim Segurado² 

[1] ,University of São Paulo School of Medicine Department of Infectious DiseasesSão Paulo SP ,Brazil

关键词: Hepatitis C virus;    Human T-lymphotropic virus type 1;    Human T-lymphotropic virus type 2;    Epidemiological studies;    Discriminant analysis;    Vírus da hepatite C;    Vírus linfotrópico de células T humanas do tipo 1;    Vírus linfotrópico de células T humanas do tipo 2;    Estudos epidemiológicos;    Análise discriminante;   

DOI  :  10.1590/S0037-86822009000400001

来源: SciELO

【 摘 要 】

Twenty-four hepatitis C virus patients coinfected with human T-lymphotropic virus type 1 were compared with six coinfected with HTLV-2 and 55 with HCV alone, regarding clinical, epidemiological, laboratory and histopathological data. Fischer's discriminant analysis was applied to define functions capable of differentiating between the study groups (HCV, HCV/HTLV-1 and HCV/HTLV-2). The discriminant accuracy was evaluated by cross-validation. Alcohol consumption, use of intravenous drugs or inhaled cocaine and sexual partnership with intravenous drug users were more frequent in the HCV/HTLV-2 group, whereas patients in the HCV group more often reported abdominal pain or a sexual partner with hepatitis. Coinfected patients presented higher platelet counts, but aminotransferase and gamma-glutamyl transpeptidase levels were higher among HCV-infected subjects. No significant difference between the groups was seen regarding liver histopathological findings. Through discriminant analysis, classification functions were defined, including sex, age group, intravenous drug use and sexual partner with hepatitis. Cross-validation revealed high discriminant accuracy for the HCV group.

【 授权许可】

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