Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis in rats

Revista da Sociedade Brasileira de Medicina Tropical

Carolina Cincurá Silva Santos¹  Záira Onofre-nunes¹  Zilton Araujo Andrade¹ 

[1] ,Fundação Oswaldo Cruz Centro de Pesquisas Gonçalo Moniz Laboratório de Patologia ExperimentalSalvador BA ,Brasil

关键词: Hepatectomy;    Fibrosis;    Capillaria hepatica;    Hepatotectomia;    Fibrose;    Capillaria hepatica;   

DOI  :  10.1590/S0037-86822007000500001

来源: SciELO

【 摘 要 】

It is known that hepatic fibrosis may regress following partial hepatectomy, since the hepatic parenchyma regenerates very rapidly, but not the excess of fibrous tissue. The present study evaluated this hypothesis by observing the behavior of systematized septal fibrosis induced by either 30 or 90-day-old Capillaria hepatica infection, in rats subjected to partial hepatectomy. The results revealed that the morphology of the fibrosis was unaffected, but its relative quantity within the microscope field appeared significantly decreased, as a consequence of the increased liver tissue mass following regeneration.

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