Role of partial hepatectomy on Capillaria hepatica-induced hepatic fibrosis in rats

Revista da Sociedade Brasileira de Medicina Tropical

Onofre-Nunes, Záira¹  Santos, Carolina Cincurá Silva¹  Fundação Oswaldo Cruz, Salvador, Brasil¹  Andrade, Zilton Araujo¹ 

关键词: Hepatectomy;    Fibrosis;    Capillaria hepatica;   

DOI  :  10.1590/S0037-86822007000500001

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

It is known that hepatic fibrosis may regress following partial hepatectomy, since the hepatic parenchyma regenerates very rapidly, but not the excess of fibrous tissue. The present study evaluated this hypothesis by observing the behavior of systematized septal fibrosis induced by either 30 or 90-day-old Capillaria hepatica infection, in rats subjected to partial hepatectomy. The results revealed that the morphology of the fibrosis was unaffected, but its relative quantity within the microscope field appeared significantly decreased, as a consequence of the increased liver tissue mass following regeneration.

【 授权许可】

Unknown