Reinfections with strains of Trypanosoma cruzi, of different biodemes as a factor of aggravation of myocarditis and myositis in mice

Revista da Sociedade Brasileira de Medicina Tropical

Sonia Gumes Andrade¹  Rozália Figueira Campos¹  Karina Souza Castro Sobral¹  Juracy Barbosa Magalhães¹  Ricardo S. Pereira Guedes¹  Marcos Lázaro Guerreiro¹ 

[1] ,Fundação Oswaldo Cruz Centro de Pesquisas Gonçalo Moniz Laboratório de Chagas Experimental, Autoimunidade e Imunologia CelularSalvador BA

关键词: Biodemes;    Chagas' disease;    Reinfections;    Trypanosoma cruzi;    Zymodemes;    Biodemas;    Doença de Chagas;    Reinfecções;    Trypanosoma cruz;    Zimodemas;   

DOI  :  10.1590/S0037-86822006000100001

来源: SciELO

【 摘 要 】

Reinfections with Trypanosoma cruzi in patients from endemic areas have been claimed to be an aggravation factor of cardiac manifestations in Chagas' disease. In the present study, the influence of triple infections with strains of different biodemes, on cardiac and skeletal muscle lesions was experimentally tested. Fifty eight mice chronically infected with the Colombian strain (Biodeme Type III) were successively reinfected as follows: 1st group - reinfected with 21 SF strain (Type II) followed by Y strain (Type I ); 2nd - group reinfections with Y strain followed by 21SF strain. Isoenzyme analysis of parasites from hemocultures obtained from triple infected mice, revealed the patterns of three distinct zymodemes in the same animal. Each Trypanosoma cruzi strain was reisolated after four passages in mice on either the 7th, 14th or 30th day after inoculation with the blood of triple infected mice. Histopathology results demonstrated a significant exacerbation of cardiac and skeletal muscle inflammatory lesions, confirmed by morphometric evaluation, in mice with triple infection. No aggravation of parasitism was detected. The possibility of an enhancement of cellular response in the triple infected mice is suggested.

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