Revista da Sociedade Brasileira de Medicina Tropical | |
Reinfections with strains of Trypanosoma cruzi, of different biodemes as a factor of aggravation of myocarditis and myositis in mice | |
Campos, Rozália Figueira1  Guedes, Ricardo S. Pereira1  Sobral, Karina Souza Castro1  Andrade, Sonia Gumes1  Fundação Oswaldo Cruz, Salvador1  Universidade Estadual de Feira de Santana, Feira de Santana, Brasil1  Magalhães, Juracy Barbosa1  Guerreiro, Marcos Lázaro1  | |
关键词: Biodemes; Chagas' disease; Reinfections; Trypanosoma cruzi; Zymodemes; | |
DOI : 10.1590/S0037-86822006000100001 | |
学科分类:农业科学(综合) | |
来源: Sociedade Brasileira de Medicina Tropical | |
【 摘 要 】
Reinfections with Trypanosoma cruzi in patients from endemic areas have been claimed to be an aggravation factor of cardiac manifestations in Chagas' disease. In the present study, the influence of triple infections with strains of different biodemes, on cardiac and skeletal muscle lesions was experimentally tested. Fifty eight mice chronically infected with the Colombian strain (Biodeme Type III) were successively reinfected as follows: 1st group - reinfected with 21 SF strain (Type II) followed by Y strain (Type I ); 2nd group reinfections with Y strain followed by 21SF strain. Isoenzyme analysis of parasites from hemocultures obtained from triple infected mice, revealed the patterns of three distinct zymodemes in the same animal. Each Trypanosoma cruzi strain was reisolated after four passages in mice on either the 7th, 14th or 30th day after inoculation with the blood of triple infected mice. Histopathology results demonstrated a significant exacerbation of cardiac and skeletal muscle inflammatory lesions, confirmed by morphometric evaluation, in mice with triple infection. No aggravation of parasitism was detected. The possibility of an enhancement of cellular response in the triple infected mice is suggested.
【 授权许可】
Unknown
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