Production of septal fibrosis of the liver by means of foreign protein injections into rats

Revista da Sociedade Brasileira de Medicina Tropical

Bruna Magalhães Gotardo¹  Rodrigo Guimarães Andrade¹  Ludmila Fernandes Oliveira¹  Zilton A. Andrade² 

[1] ,Fundação Oswaldo Cruz Centro de Pesquisas Gonçalo Moniz Laboratory of Experimental PathologySalvador BA ,Brasil

关键词: Capillaria hepatica;    Hepatic fibrosis;    Pig-serum model;    Capillaria hepatica;    Fibrose septal hepática;    Modelo do soro de porco;   

DOI  :  10.1590/S0037-86822003000500006

来源: SciELO

【 摘 要 】

Similarities and differences in antigenic humoral responses and electrophoretic patterns between Capillaria hepatica and pig-serum were investigated as a contribution to the understanding of hepatic fibrosis induced by the parenteral administration of foreign proteins. Only two out of 10 rats receiving repeated intraperitoneal injections of an extract of Capillaria hepatica-infected mouse liver presented septal hepatic fibrosis (20%). Under the same experimental conditions, 4 out of 9 rats (44.4%) developed septal fibrosis following whole pig-serum administration. Injections of normal mouse liver extracts did not result in hepatic fibrosis. Since a 100% septal fibrosis rate is observed in experimentally Capillaria hepatica-infected rats, it appeared that Capillaria hepatica products continuously released from inside the liver creates a much more effective fibrosis inducing mechanism than the parenteral administration of such factors. Thus, repeated peritoneal administration of a foreign protein to rats would not reveal the full fibrogenic potential it may have under natural conditions.

【 授权许可】

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