Structural changes in the jejunal mucosa of mice infected with Schistosoma mansoni, fed low or high protein diets

Revista da Sociedade Brasileira de Medicina Tropical

Janira Lúcia Assumpção Couto²  Haroldo Da Silva Ferreira¹  Dinalva Bezerra Da Rocha¹  Maria Eugênia Leite Duarte¹  Monica Lopes Assunção¹  Eridan De Medeiros Coutinho¹ 

[1] ,Universidade Federal de Alagoas Centro de Ciências Biológicas Departamento de ParasitologiaMaceió AL

关键词: Schistosoma mansoni;    Undernutrition;    Mice;    Intestinal mucosa;    Histomorphometry;    Schistosoma mansoni;    Desnutrição;    Camundongo;    Mucosa intestinal;    Histomorfometria;   

DOI  :  10.1590/S0037-86822002000600010

来源: SciELO

【 摘 要 】

The effects of high and low-protein diets on the structure of the jejunal mucosa were studied in Schistosoma mansoni infected mice (morphology and histomorphometry). Weaning male albino mice were infected with 80 cercariae, fed with high (20%) or low-protein (5%) diets and compared to uninfected controls under the same conditions. Mice were sacrificed 12 weeks after infection. Animals submitted to a low-protein diet showed lower weight curves, mainly when infected. In the jejunal mucosa, finger-like villi were the predominant pattern among uninfected high-protein fed animals, while the infected ones showed leaf-shaped and flattened villi in most cases. Undernourished infected mice had 65.7% leaf-shaped villi. A significant increase in the number of goblet cells was seen in infected mice. A decrease in the number of absorptive cells was detected in undernourished mice, particularly in infected ones.

【 授权许可】

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