Structural changes in the jejunal mucosa of mice infected with Schistosoma mansoni, fed low or high protein diets

Revista da Sociedade Brasileira de Medicina Tropical

Coutinho, Eridan de Medeiros¹  Universidade Federal de Alagoas, Maceió, AL¹  Universidade Federal de Alagoas, Maceió¹  Fundação Oswaldo Cruz, Recife, Brasil¹  Duarte, Maria Eugênia Leite¹  Assunção, Monica Lopes¹  Universidade Federal Fluminense, Niterói¹  Escola de Ciências Médicas de Alagoas, Maceió¹  Couto, Janira Lúcia Assumpção¹  Ferreira, Haroldo da Silva¹  Rocha, Dinalva Bezerra da¹ 

关键词: Schistosoma mansoni;    Undernutrition;    Mice;    Intestinal mucosa;    Histomorphometry;   

DOI  :  10.1590/S0037-86822002000600010

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The effects of high and low-protein diets on the structure of the jejunal mucosa were studied in Schistosoma mansoni infected mice (morphology and histomorphometry). Weaning male albino mice were infected with 80 cercariae, fed with high (20%) or low-protein (5%) diets and compared to uninfected controls under the same conditions. Mice were sacrificed 12 weeks after infection. Animals submitted to a low-protein diet showed lower weight curves, mainly when infected. In the jejunal mucosa, finger-like villi were the predominant pattern among uninfected high-protein fed animals, while the infected ones showed leaf-shaped and flattened villi in most cases. Undernourished infected mice had 65.7% leaf-shaped villi. A significant increase in the number of goblet cells was seen in infected mice. A decrease in the number of absorptive cells was detected in undernourished mice, particularly in infected ones.

【 授权许可】

Unknown