Isolation of dengue 2 virus from a patient with central nervous system involvement (transverse myelitis)

Revista da Sociedade Brasileira de Medicina Tropical

Raimundo N.q. Leão²  Teichi Oikawa¹  Elizabeth S.t. Rosa¹  José T. Yamaki¹  Sueli G. Rodrigues¹  Helena B. Vasconcelos¹  Maria R.s. Sousa¹  Jaime K. Tsukimata¹  Raimunda S.s. Azevedo¹  Pedro F.c. Vasconcelos¹ 

[1] ,Universidade do Estado do Pará Departamento de Saúde Comunitária Belém PA ,Brazil

关键词: Dengue fever;    Transverse myelitis;    Dengue 2;    Virus isolation;    RT-PCR;    Febre clássica do dengue;    Mielite transversa;    Dengue 2;    Isolamento viral;    RT-PCR;   

DOI  :  10.1590/S0037-86822002000400018

来源: SciELO

【 摘 要 】

A dengue fever case is described in a 58-year-old male patient with febrile illness and thrombocytopenia complicated by neurological involvement characterized by transverse myelitis followed by weakness of both legs and flaccid paralysis. Muscle strength was much diminished and bilateral areflexia was observed. Dengue 2 (DEN-2) virus was isolated and the patient sero-converted by hemagglutination-inhibition and IgM-ELISA tests. The RT-PCR test was positive to DEN-2 in acute phase serum and culture supernatant, but negative in the cerebrospinal fluid. After three weeks of hospitalization the patient was discharged. No other infectious agent was detected in the blood and cerebrospinal fluid samples. The patient had full recovery from paralysis six months after the onset of DEN-2 infection.

【 授权许可】

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