Isolation of dengue 2 virus from a patient with central nervous system involvement (transverse myelitis)

Revista da Sociedade Brasileira de Medicina Tropical

Oikawa, Teichi¹  Rosa, Elizabeth S.T.¹  Hospital Amazônia, Belém, Brazil¹  Tsukimata, Jaime K.¹  Rodrigues, Sueli G.¹  World Health Organization¹  Azevedo, Raimunda S.S.¹  Yamaki, José T.¹  Vasconcelos, Pedro F.C.¹  Universidade do Estado do Pará, Belém, Brazil¹  Ministério da Saúde, Belém, Brazil¹  Universidade Federal do Pará, Belém, Brazil¹  Leão, Raimundo N.Q.¹  Sousa, Maria R.S.¹  Vasconcelos, Helena B.¹ 

关键词: Dengue fever;    Transverse myelitis;    Dengue 2;    Virus isolation;    RT-PCR;   

DOI  :  10.1590/S0037-86822002000400018

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

A dengue fever case is described in a 58-year-old male patient with febrile illness and thrombocytopenia complicated by neurological involvement characterized by transverse myelitis followed by weakness of both legs and flaccid paralysis. Muscle strength was much diminished and bilateral areflexia was observed. Dengue 2 (DEN-2) virus was isolated and the patient sero-converted by hemagglutination-inhibition and IgM-ELISA tests. The RT-PCR test was positive to DEN-2 in acute phase serum and culture supernatant, but negative in the cerebrospinal fluid. After three weeks of hospitalization the patient was discharged. No other infectious agent was detected in the blood and cerebrospinal fluid samples. The patient had full recovery from paralysis six months after the onset of DEN-2 infection.

【 授权许可】

Unknown