Combined effect of the essential oil from Chenopodium ambrosioides and antileishmanial drugs on promastigotes of Leishmania amazonensis

Revista do Instituto de Medicina Tropical de São Paulo

Lianet Monzote²  Ana Margarita Montalvo²  Ramón Scull¹  Migdalia Miranda¹  Juan Abreu¹ 

[1] ,Instituto de Medicina Tropical Pedro Kourí Departamento de Parasitología Ciudad de la Habana,Cuba

关键词: Leishmania amazonensis;    Chenopodium ambrosioides;    Combination therapy;   

DOI  :  10.1590/S0036-46652007000400012

来源: SciELO

【 摘 要 】

To date, there are no vaccines against Leishmania, and chemotherapy remains the mainstay for the control of leishmaniasis. The drugs of choice used for leishmaniasis therapy are significantly toxic, expensive and with a growing frequency of refractory infections. Because of these limitations, a combination therapy is the better hope. This work demonstrates that the essential oil from Chenopodium ambrosioides shows a synergic activity after incubation in conjunction with pentamidine against promastigotes of Leishmania amazonensis. However, an indifferent effect has been found for combinations of meglumine antimoniate or amphotericin B and the essential oil.

【 授权许可】

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