Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae

Revista do Instituto de Medicina Tropical de São Paulo

Walter Belda Junior²  Paulo Eduardo Neves Ferreira Velho¹  Luiz Jorge Fagundes¹  Marcelo Arnone² 

[1] ,São Paulo University Department of Dermatology São Paulo SP ,Brazil

关键词: Gonorrhea;    Neisseria gonorrhoeae;    Drug resistance;    Minimum inhibitory concentration;   

DOI  :  10.1590/S0036-46652007000100010

来源: SciELO

【 摘 要 】

Use of antimicrobials for the treatment of gonorrhea started in 1930 with the utilization of sulfonamides. With the years other drugs were used for its treatment such as penicillin, tetracycline, spectinomycin, and others. Although highly specific in the beginning, these drugs, with time did not show anymore the expected therapeutic results because of aspects of chromosomal and plasmid-mediated resistance. The purpose of this study was to evaluate the susceptibility of Neisseria gonorrhoeae strains to six drugs used for its treatment (penicillin, tetracycline, cefoxitin, thiamphenicol, spectinomycin and ofloxacin) by the determination of minimal inhibitory concentrations of these drugs. We concluded that drugs, such as cefoxitin, thiamphenicol and spectinomycin still are excellent pharmacological agents for the treatment of gonorrhea. Penicillin, although still efficient, needs more attention regarding its use, as well as ofloxacin, because of the emergence of resistant strains. Tetracycline and its derivatives should be strongly contraindicated for the treatment of gonorrhea.

【 授权许可】

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